Feeling exhausted and super sensitive to supplements? 😩 You might think it’s adrenal fatigue, but in many cases, it’s actually due to vitamin deficiencies—especially in those with MTHFR or FOLR2 gene mutations. These genetic variants can impair your ability to process folic acid, leading to low energy, poor adrenal output, and overmethylation. For sensitive patients, starting with hydroxy B12 and folinic acid (not folic acid) is often the safest and most effective route. Want help figuring out